Actin, a fundamental building block of intracellular cytoskeletal filaments, holds immense potential as a platform for information processing. In this groundbreaking book, the authors establish a solid theoretical and modelling foundation for the future experimental prototyping of actin-based cytoskeleton computers in laboratory settings. By delving into the mechanisms of signal propagation and perturbations on actin filaments, the authors uncover the underlying principles of information processing at the sub-cellular level. Through their innovative insights, novel principles for information processing emerge, potentially revolutionising the field of future and emergent information technologies and computational biology. The book's theoretical and modelling framework serves as a crucial stepping stone towards the experimental realisation of actin-based cytoskeleton computers. Bridging the gap between theory and practice, researchers and scientists can leverage this knowledge to conduct experiments, validate hypotheses, and explore the practical implications of actin-based computing systems.