Aging neuroscientist Andrew Hamilton, paralyzed for years due to a tragic accident, seeks to end his life by volunteering for a groundbreaking experiment in which his brain is transplanted into the body of a suddenly deceased, much younger man. Certain that the operation will fail, he is unprepared for the heartbreaking consequences which await him. His miraculous survival and transformation cause Andrew to lose everything he holds dear: his wife, his friends, his identity, and, at times, his dignity. Andrew slowly acclimates to his new virile, youthful self and begins to explore the boundaries of relationships and passion, intent upon recapturing the most valuable thing he lost: someone to love and be loved by unconditionally. But can love truly be unconditional? Can it survive a shocking transformation that leaves us face to face with someone we no longer recognize? All That Really Mattered stirs up the essential questions of what makes us who we are, what gives meaning to our lives, and whether death can ever conquer an eternal bond of love.