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Oroxylum indicum: Exploring Anticancer Potential - Kishori Apte,Ms. Dipti Joshi,Kala Suhas Kulkarni

englanti
2011-04-22
52,90 € 70,53 €

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Toimitus 15-21 arkipäivässä

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Hepatocellular Carcinoma represents about 4% of all malignancies worldwide. A number of chemopreventive phytochemicals have been identified which react with prooxidants and prevent damages to DNA thereby preventing the onset of various diseases. Thioacetamide, a model hepatotoxicant, undergoes metabolic activation to form thioacetamide sulfoxide and further metabolized to form thioacetamide-S,S,- oxide thus ... Täydellinen kuvaus

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Hepatocellular Carcinoma represents about 4% of all malignancies worldwide. A number of chemopreventive phytochemicals have been identified which react with prooxidants and prevent damages to DNA thereby preventing the onset of various diseases. Thioacetamide, a model hepatotoxicant, undergoes metabolic activation to form thioacetamide sulfoxide and further metabolized to form thioacetamide-S,S,- oxide thus initiating hepatocellular necrosis and further hepatocarcinogenesis. Thioacetamide thus produces oxidative stress on liver and causes hepatocellular carcinoma. This oxidative stress can be reversed by the use of antioxidants. Thus, the aim of this work was to evaluate the anticancer activity of hydroalcoholic extract prepared from Oroxylum indicum, correlating the biochemical and histological changes in thioacetamide induced hepatocellular carcinoma in female Sprague Dawley rats. This research work should help shed some light on cancer research and experimental model development for hepatocellular carcinoma, and should be especially useful to research scholars, scientists and students working on hepatocellular carcinoma in experimental animals.

Lisätietoja

Kirjoittaja Kishori Apte, Ms. Dipti Joshi, Kala Suhas Kulkarni
Julkaisija LAP LAMBERT Academic Publishing
Julkaisuvuosi 2011
Kannen tyyppi Pehmeäkantinen
EAN 9783844328073
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Arvostelet: Oroxylum indicum: Exploring Anticancer Potential
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52,90 € 70,53 €