Terrence Stevenson and J.B. Dawson had been friends for too many years to count. However, their friendship wasn't in mind when Terrence wanted J.B. to introduce him to a girl for whom J.B. had a thing. Against his better thoughts, J.B. made the introductions, only for Tamia to fall for his best friend. Of course, this caused a problem between two guys who swore to be there for each other.
College was over, and J.B. had given up on pursuing Tamia. Tamia and Terrence were on the fast track to becoming husband and wife. While moving into their dream home, the couple discovered they were expecting their first child but weren't expecting triplet girls. Toward the end of her pregnancy, Tamia began to experience problems, so much so that she was placed in the hospital, only to learn that she was extremely ill. Although the doctors worked to clear up the infection she had gotten, nothing worked. Tamia passed away after the delivery of her third child.
Finding that the cause of her illness stemmed from shootee work done before they purchased their home, Terrence and J.B. went after the people who had taken his wife and the mother of his three daughters. However, Terrence had no idea that soon, his daughters would work to prevent this dreaded disease from claiming another life if they could prevent it.