Russell Todaro, a young American translator, moves to Paris to take stock of his life and goals only to further lose himself in the surprising twists fate has in store for him. One night, two men waving guns and knives break and enter their Paris hotel room, terrorizing Russell and his much older companion, a famous American poet named Edward Cannon. The intruders, not finding what they seemingly expected, leave without further incident but the baffling, traumatic events overwhelm Cannon who dies in his sleep later that night. Now Russell is left to ponder the meaning of the attack, what to do with the poet's unfinished, problematic memoir and, perhaps most importantly, how to reconstruct and move forward with his own life.

Hearing of the disturbing circumstances of Cannon's death, an Italian writer, Marina Vezzoli, invites Russell to recuperate at her villa in Tuscany. But what at first seems like a generous invitation slowly reveals itself to be a calculated offer. As Russell's stay in Italy lengthens, he begins to realize that the people in his life are using or manipulating him, most of all the poet's New York publishers who, against the dying man's wishes, are trying to acquire his unfinished manuscript. Looming over everything is the long and fascinating legacy of Villa Guidi, where during Word War II a Jewish family hid in the subterranean floors, later undergoing a conversion to Catholicism. In an echo of this dramatic history, Russell is forced to undergo a conversion of his own in order to find redemption and meaning in his life.